Thiazole Derivatives and Use Thereof

A method of treating autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, allergy, asthma, pancreatitis, multi-organ failure, kidney diseases, platelet aggregation, cancer, transplantation, sperm motility, erythrocyte deficiency, graft rejection or lung injuries comprising the administration of a pharmaceutically effective amount of a compound of Formula I to an individual in need thereof, wherein said compound of Formula (I) is

• wherein:
• R1 is selected from H, acyl, or a substituted acyl;
• R2 is a C1-C6-alkyl, or substituted C1-C6-alkyl;
• R3 is selected from the following thienyl groups, defined as T1 and T2:
• wherein:
• R4 is selected from:
• a sulfonyl group SO2—R, wherein R is selected from heteroaryl or heterocycloalkyl;
• and
• R5 and R6 are independently selected from H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl groups;
• a substituted C1-C6-alkyl, substituted C2-C6-alkenyl, substituted C2-C6-alkynyl groups or halogen;
• and isomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof.