Combinations of a pi3k inhibitor and a mek inhibitor
AssigneeGenentech, Inc.
InventorsMarcia Belvin, Iris T. Chan, Lori Friedman, Klaus P. Hoeflich, John Prescott, Jeffrey Wallin
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Abstract
The invention relates methods of treating a patient with locally advanced or metastatic solid tumors with a combination of an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase or PI3K) and an inhibitor of mitogen activated protein kinase (MEK) described herein.
Claims14
A method for the treatment of a patient with a locally advanced or metastatic solid tumor comprising administering a therapeutic combination, as a combined formulation or by alternation, to a mammal wherein the therapeutic combination comprises a therapeutically effective amount of a compound of formula I or II, or a pharmaceutically acceptable salt of I or II, and a
- therapeutically effective amount of a compound of formula III, or a pharmaceutically acceptable salt of III.
Dependencies are inferred from the claim text.