Compositions and methods for treating obesity

A method of treating obesity in a subject, comprising administering to the subject a pharmaceutical formulation comprising hyodeoxycholic acid (HDCA) or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to reduce the subject's body weight by at least 5% within three months after an onset of administration.

A method of treating obesity, comprising administering to a subject a pharmaceutical formulation comprising hyodeoxycholic acid (HDCA) or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to induce in a first patient population a mean weight loss that exceeds, by at least 5%, a mean weight loss observed in second patient population to whom a placebo was administered.

A method of treating obesity in a subject, comprising administering to the subject a pharmaceutical formulation comprising hyodeoxycholic acid (HDCA) or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to result in a proportion of subjects receiving the formulation who reach and maintain for at least one year a loss of at least 5% of their body weight to be significantly greater than a proportion of subjects receiving a placebo who reach and maintain for at least one year a loss of at least 5% of their body weight.