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US 2011/0086828 A1Published application
Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorPeter Winsauer
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Abstract
The present invention provides methods for reducing alcohol drinking behavior in humans and treating acute alcohol poisoning through the use of neutral or negative modulating agents of the neurosteroid sites on GABAA receptors. These agents avoid the unwanted side-effects of opiate antagonists and displays specificity toward the neurosteroid binding sites on GABAA receptors.
Claims9
A method for therapeutically treating alcoholism in humans, comprising:
- administration of an effective amount of a composition comprising a modulating agent in a pharmaceutically acceptable vehicle to an individual in need of treatment to reduce alcohol intake, wherein the modulating agent demonstrates specificity to the neurosteroid binding sites on GABAA receptor complexes.
A method for therapeutically treating acute alcohol poisoning in humans, comprising:
- administration of an effective amount of a composition comprising a modulating agent in a pharmaceutically acceptable vehicle to an individual in need of treatment of acute alcohol poisoning, wherein the modulating agent demonstrates specificity to the neurosteroid binding sites on GABAA receptor complexes.
Dependencies are inferred from the claim text.