Novel phosphonic acid compounds as inhibitors of serine proteases

A compound of Formula (Ia):

• wherein:
• R7 is selected from the group consisting of hydrogen, C1-8 alkyl and C2-8 alkenyl;
• and,
• R8 is selected from the group consisting of piperazine and piperidine,
• optionally substituted with one to four substituents independently selected from the group consisting of:
• C1-4 alkyl, carbonyl (substituted with a substituent selected from the group consisting of C1-4 alkyl, aryl, aryl(C1-4)alkyl and aryl(C2-4)alkenyl) and aryl;
• wherein the aryl substituent and the aryl portions of the carbonyl substituent are optionally substituted with one to two substituents independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, di(C1-4 alkyl)amino, halogen, hydroxy and (halo)1-3(C1-4)alkyl;
• and isomers, racemates, enantiomers, diastereomers and salts thereof.