Polypeptides that Bind IL-23R
AssigneeAnaphore, Inc.
InventorsAnke Kretz-Rommel, Martha Wild, Katherine S. Bowdish, Elise Chen, Daniela Oltean, Maria Gonzalez, Mili Kapoor
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Abstract
Polypeptides that bind to IL-23R including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds IL-23R. The multimerizing domain may be derived from human tetranectin. IL-23R binding polypeptides inhibit activation of IL-23R by native IL-23 and can be used as therapeutics agents for a variety of immune related disorders and cancers. Methods for selecting polypeptides and preparing multimeric complexes are described.
Claims34
A polypeptide comprising a trimerizing domain and at least one polypeptide sequence that binds to human IL-23R without activating IL-23 heterodimeric receptor.
A method for preparing a polypeptide that mediates an immune related disorder comprising:
- a) creating a library of polypeptides comprising a CTLD comprising at least one randomized loop region;
- b) selecting a first polypeptide from the library that binds IL-23R but does not bind to at least one of IL-12Rβ1 or IL-12Rβ2.
A polypeptide that competes with native human IL-23 for binding to native IL-23R, wherein the polypeptide does not activate human IL-23R and does not bind to at least one of IL-12Rβ1 or IL-12Rβ2.
The polypeptide of claim 30 wherein, the polypeptide is a CTLD that has been modified in one of loops 1, 2, 3 or 4 of loop segment A or in loop segment B for binding to IL-23R.
A host cell comprising the vector of claim 34.
Dependencies are inferred from the claim text.