In vitro method for diagnosing skin cancer
AssigneeAssistance Publique-Hopitaux de Paris
InventorNadem Soufir
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Abstract
The present invention relates to an in vitro method for identifying an individual suffering from or having a predisposition to skin cancer, characterized in that it comprises the step of analysing a biological sample originating from said individual by a) detecting a polymorphism of the MATP/SLC45A2 gene (SEQ ID NO: 1), and/or analysing the expression of the MATP/SLC45A2 gene; to the use, for preparing a composition for the treatment and/or prevention of a skin cancer in an individual, of a compound which specifically increases the expression of the MATP/SLC45A2 gene in a skin cell; and to a method for the selection, in vitro, of a compound capable of being of use in the treatment of skin cancer.
Claims13
An in vitro method intended to identify a subject affected with or having a predisposition to skin cancer, wherein it comprises analyzing a biological sample from said subject by:
- a) detection of a polymorphism of a MATP/SLC45A2 gene (SEQ ID NO:1), and/or
- b) analysis of the expression of the MATP/SLC45A2 gene.
A method for treating and/or preventing skin cancer in a patient in need thereof, comprising the administration of an effective amount of a compound which specifically increases the expression of the MATP/SLC45A2 gene in a skin cell.
A method for selecting in vitro a compound capable of being useful for treating skin cancer, wherein it comprises:
- a) obtaining a cell expressing the MATP/SLC45A2 gene;
- b) putting said cell in contact with at least one compound to be tested;
- c) comparing the expression of the MATP/SLC45A2 gene between steps a) and b);
- and
- d) selecting the compound inducing an increase in the expression level of the MATP/SLC45A2 gene in the cell in step b) relatively to the expression level of said gene in step a).
Dependencies are inferred from the claim text.