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AssigneeHarvard University
InventorsZHAOXI WANG, DOUGLAS BEACH, LI SU, RIHONG ZHAI, DAVID C. CHRISTIANI
Estimating the term…
The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin present in a subject sample, or by determining the ration of elafin:neutrophil elastase in a subject sample. The invention also features methods for monitoring the efficacy of a treatment regimen for ARDS as well as methods of treatment for ARDS. The invention also features methods to determine a subject's predisposition for developing ARDS by determining whether certain genomic polymorphisms are present in the subject's DNA.
A method of predicting whether a subject is at high risk of developing Acute Respiratory Distress Syndrome (ARDS) the method comprising:
A method of monitoring clinical progress of a subject who has or is at high risk of developing Acute Respiratory Distress Syndrome (ARDS) the method comprising:
3-9. (canceled)
A kit for determining the amount of elafin in a test sample from a subject who has or is at high risk of developing Acute Respiratory Distress Syndrome (ARDS) comprising:
A method of treating Acute Respiratory Distress Syndrome (ARDS) in a subject comprising:
(canceled)
A method for determining the predisposition of a subject to develop ARDS comprising determining whether the genome of the subject comprises at least one single nucleotide polymorphism (SNP) associated with an increased risk of ARDS, to thereby determine the predisposition of the subject to develop ARDS.
15-16. (canceled)
A diagnostic kit comprising an oligonucleotide that specifically detects a human elafin nucleotide polymorphism.
18-27. (canceled)
29-30. (canceled)
A method of determining the predisposition of a subject to develop Acute Respiratory Distress Syndrome (ARDS) the method comprising determining whether the genome of the subject comprises haplotype Hap2 (TTC);
33-43. (canceled)
Dependencies are inferred from the claim text.