Surfactant-Based Monolithic Columns, Methods for Making the Same, and Method for Using the Same
AssigneeGeorgia State University Research Foundation, Inc.
InventorsShahab Ahmed Shamsi, Jun He, Congying Gu
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Abstract
A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.
Claims29
A method for making a surfactant-based monolithic column, the method comprising:
- providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen;
- and
- polymerizing the mixture to form the surfactant-based monolithic column. I0
A surfactant-based monolithic column comprising:
- a surfactant-based polymer monolith.
A method for separating a plurality of molecules from each other comprising:
- providing a surfactant-based monolithic column;
- providing a mixture of the plurality of molecules and a mobile phase;
- and
- passing the mixture through the surfactant-based monolithic column.
A process for preparing a surfactant monomer, the process comprising:
- a providing a carboxylic acid having a carbon chain length ranging from about 6 to about 20 and a tail group, wherein the tail group comprises NH2, or OH;
- reacting the carboxylic acid with aryloyl chloride to form a first product;
- reacting the first product with 1-hydroxypyrrolidine-2,5-dione to form a second product;
- and
- reacting the second product with an amino acid to form the surfactant monomer including an amino acid functional group.
Dependencies are inferred from the claim text.