Methods for Repairing Degraded DNA
AssigneeIbis Biosciences, Inc.
InventorMark W. Eshoo
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Abstract
The present invention provides methods and kits for repair of degraded DNA which may then be used as a template for efficient amplification by a number of different amplification reactions. The method relies upon a series of enzymatic activities provided by DNA repair enzymes.
Claims19
-29. (canceled)
A kit comprising an endonuclease, a DNA N-glycosylase, an AP lyase, a DNA polymerase, a 3′-diesterase, a polynucleotide kinase, and a DNA ligase.
A composition comprising any two or more enzymes having endonuclease activity, DNA N-glycosylase activity, AP lyase activity, polymerase activity, 3′-diesterase activity, polynucleotide kinase activity, or DNA ligase activity.
Dependencies are inferred from the claim text.