Organ-on-a-chip-device

A self-contained organ-on-a-chip device comprising:

• at least one medium feed reservoir;
• and
• at least one organ growth section includes at least one organ cavity,
• wherein the at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity.

A supply unit configured to hold a self-contained organ-on-a-chip device comprising:

• at least one medium feed reservoir, and
• at least one organ growth section including at least one organ cavity,
• wherein the at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity during operation, the supply unit comprising:
• a holding device configured to releasably engage the self-contained organ-on-a-chip device;
• and
• electric connectors configured to connect to corresponding connectors on the self-contained organ-on-a-chip device to the supply unit.

A method of providing at least one of an organ and an organoid in a self-contained organ-on-a-chip device comprising:

• at least one medium feed reservoir, and
• at least one organ growth section including at least one organ cavity,
• wherein the at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity, the method comprising:
• loading a suspension of cells or a tissue slice into at least one organ cavity;
• and
• sealing the at least one organ cavity so as to be fluid-tight.

A method of testing the effect of at least one test compound on at least one of an organ and an organoid in a self-contained organ-on-a-chip device comprising:

• at least one medium feed reservoir, and
• at least one organ growth section including at least one organ cavity,
• wherein the at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity, the method comprising:
• providing the self-contained organ-on-a-chip device comprising at least one of an organ and an organoid,
• or
• carrying out a method of establishing at least one of an organ and an organoid in the self-contained organ-on-a-chip device, the method comprising:
• loading a suspension of cells or a tissue slice into at least one organ cavity, and
• sealing the at least one organ cavity so as to be fluid-tight;
• adding the at least one test compound to the at least one of an organ and an organoid;
• and
• at least one of assessing the at least one of an organ and an organoid microscopically and determining one or more parameters by at least one sensor.

Method of using a self-contained organ-on-a-chip device comprising:

• at least one medium feed reservoir, and
• at least one organ growth section including at least one organ cavity,
• wherein the at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity, the method comprising:
• providing the self-contained organ-on-a-chip device comprising at least one of an organ and an organoid;
• and either
• testing at least one effect of at least one test compound on the at least one of an organ and an organoid,
• or
• examining the at least one of an organ an organoid function with the at least one of an organ and an organoid.