Method for evaluation of function of phagocyte
AssigneeMochida Pharmaceutical Co., Ltd.
InventorKatsuki Naito
Life of this patent
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Abstract
A novel convenient method for evaluating the function of a phagocyte is provided. The method assays sCD14-ST, which is a humoral factor specifically produced in phagocytosis by the phagocyte and which is stable enough for use in an assay. Also provided is a method for detecting diseases associated with the phagocytosis by the phagocyte.
Claims13
A method for evaluating the function of a phagocyte comprising the steps of
- 1) bringing a phagocyte in contact with a substance to be engulfed by the phagocyte,
- 2) measuring sCD14-ST produced by the phagocyte, and
- 3) comparing the measured value with a standard value to determine the presence and/or degree of the phagocytic activity of the phagocyte.
A method for detecting a disease associated with the phagocyte dysfunction by evaluating the function of a phagocyte, comprising the steps of
- 1) evaluating the function of a phagocyte collected from a subject by the method of claim 1,
- 2) comparing the evaluation result with a normal value, and
- 3) determining the presence and/or severity of the disease based on whether the function of the phagocyte from the subject is higher or lower than the normal value.
A method for screening a substance capable of regulating phagocytosis function comprising the steps of
- 1) bringing a phagocyte in contact with an analyte,
- 2) measuring sCD14-ST produced by the phagocyte, and
- 3) evaluating the effect of the analyte on the phagocytic activity of the phagocyte.
A method for detecting a disease associated with phagocytosis by a phagocyte comprising the steps of
- 1) measuring the amount of sCD14-ST in a specimen (which is not blood) from the donor,
- 2) comparing the evaluation result with a normal value, and
- 3) determining whether the amount of the sCD14-ST in the specimen is higher than the normal value.
A marker for evaluating the function of a phagocyte containing sCD14-ST.
Dependencies are inferred from the claim text.