Urine and serum biomarkers associated with diabetic nephropathy
AssigneeIndustrial Technology Research Institute (ITRI)
InventorsWei-Ya Lin, Mary Ya-Ping Yeh, Tzu-Ling Tseng, Ping-Fu Cheng, Tsai-Wei Hsu, Hung-Yi Li, Yi-Ting Chen, Yuh-Feng Ling, Jin-Shuen Chen, Yen-Peng Li
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Abstract
Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.
Claims16
An isolated antibody specifically binding to a peptide selected from the group consisting of:
- (SEQ ID NO:
- 2)
- MGVVSLGSPSGEVSHPRKT,
- (SEQ ID NO:
- 3)
- KGKWERPFEVKDTEEEDF,
- (SEQ ID NO:
- 4)
- MIEQNTKSPLFMGKVVNPTQK,
- (SEQ ID NO:
- 6)
- EDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFA,
- (SEQ ID NO:
- 7)
- GQEHFAHLLILRDTKTYMLADVNDEKNWGLS,
- (SEQ ID NO:
- 8)
- YPDAVATWLNPDPSQKQ NLLAPQNAVSSEETNDFKQETLPSK,
- and
- (SEQ ID NO:
- 9)
- KYPDAVATWLNPDPSQKQNLLAPQTLPSK.
A kit for diagnosing diabetic nephropathy, comprising two, three, or four antibodies, each of which is capable of binding to (i) alpha-2-HS-glycoprotein, (ii) alpha-1 antitrypsin, (iii) alpha-1 acid glycoprotein, or (iv) osteopontin, wherein the two, three, or four antibodies have different antigen specificities.
Dependencies are inferred from the claim text.