Method for immune response detection
AssigneeDrexel University
InventorsWAN Y. SHIH, JOSEPH CAPOBIANCO, WEI-HENG SHIH, HOSSEIN BORGHAEI
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Abstract
A method for detecting one or more immunological response factors that is expressed in response to a therapeutic treatment and/or disease using a piezoelectric microcantilever sensor (PEMS) to assess a patient's immunological response. The method involves measuring a frequency shift of the PEMS caused by binding the immunological response factors to one or more receptors on the PEMS. The method may be used to determine the effectiveness of a prescribed therapeutic treatment and/or monitor the progress of a disease.
Claims24
A method for detecting an immunological response comprising the steps of:
- (a) contacting a piezoelectric microcantilever sensor having a receptor immobilized thereon which specifically binds an immunological response factor with a sample of interest,
- (b) measuring a resonance frequency shift of the piezoelectric microcantilever sensor caused by binding of said immunological response factor in said sample of interest to said receptor on said piezoelectric microcantilever sensor, and
- (c) determining an immunological response from said measured resonance frequency shift.
Dependencies are inferred from the claim text.