Polymeric systems for the delivery of anticancer drugs
AssigneeRexahn Pharmaceuticals, Inc.
InventorsYoung B. Lee, Deog J. Kim, Chang H. Ahn
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Abstract
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker.
Claims20
A therapeutic composition comprising a first polymer carrier, wherein the first polymer carrier comprises
- a) a first monomer selected from the group consisting of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(3-aminopropyl)methacrylamide (3-APMA), and N-(2-aminopropyl)methacrylamide (2-APMA);
- and
- b) a first anticancer agent attached to the first polymer carrier, optionally through a linker;
- wherein the first anticancer agent is attached to the first monomer or to another monomer.
Dependencies are inferred from the claim text.