Dispersinb, 5-Fluorouracil, Deoxyribonuclease I and Proteinase K-Based Antibiofilm Compositions and Uses Thereof

A method of inhibiting proliferation of biofilm-embedded microorganisms comprising administering two or more compounds selected from the group consisting of:

• (a) a family 20 glycosyl hydrolase, or active fragment, variant, ortholog, allelic variant, or functional equivalent thereof;
• (b) 5-fluorouracil;
• (c) deoxyribonuclease I or an active fragment or variant thereof;
• and (d) Proteinase K or an active fragment or variant thereof.

A method of treating a disease-related infection caused by biofilms comprising administering two or more compounds selected from the group consisting of:

• (a) a family 20 glycosyl hydrolase, or active fragment, variant, ortholog, allelic variant, or functional equivalent thereof;
• (b) 5-fluorouracil;
• (c) deoxyribonuclease I or an active fragment or variant thereof;
• and (d) Proteinase K or an active fragment or variant thereof.

A method of treating a wound comprising administering two or more compounds selected from the group consisting of:

• (a) a family 20 glycosyl hydrolase, or active fragment, variant, ortholog, allelic variant, or functional equivalent thereof;
• (b) 5-fluorouracil;
• (c) deoxyribonuclease I or an active fragment or variant thereof;
• and (d) Proteinase K or an active fragment or variant thereof.

A method of treating an oral infection or disease comprising administration of two or more compounds selected from the group consisting of:

• (a) a family 20 glycosyl hydrolase, or active fragment, variant, ortholog, allelic variant, or functional equivalent thereof;
• (b) 5-fluorouracil;
• (c) deoxyribonuclease I or an active fragment or variant thereof;
• and (d) Proteinase K or an active fragment or variant thereof.