Loading patent…
AssigneeK.U. Leuven Research & Development
InventorsJohan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck
Estimating the term…
The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.
A pharmaceutical composition comprising a biologically active species and a substantially ordered mesoporous oxide based material, wherein said ordered oxide based material has one or more levels of porosity or structural order, provided that when said ordered oxide based material has a single level of porosity and structural order it has a pore size in the range 4 nm to 14 nm and is obtained in the absence of an alpha-tocopherol polyethylene glycol ester templating biomolecule.
A process for producing a pharmaceutical composition comprising a biologically active species and a substantially ordered mesoporous oxide based material, wherein a physical mixture of said biologically active species and said substantially ordered mesoporous oxide based material is suspended in an appropriate solvent other than a supercritical fluid, and the suspended mixture is stirred until the biologically active species is substantially entirely fixed or entrapped within the pores of the ordered mesoporous oxide based material.
A substantially crystalline mesoporous oxide based material being obtained by assembly of nanometer size building units having zeolite framework, wherein said assembly proceeds in the presence of one or more amphiphilic non-anionic surfactants, wherein said substantially crystalline mesoporous oxide based material has two or more levels of porosity and structural order, and wherein the internal structure of said nanometer size building units does not give rise to Bragg type diffraction in a powder X-ray diffraction pattern of said substantially crystalline mesoporous oxide based material.
A process for making a substantially crystalline mesoporous oxide based material being obtained by assembly of nanometer size building units having zeolite framework, wherein said assembly proceeds in the presence of one or more amphiphilic non-anionic surfactants, wherein said substantially crystalline mesoporous oxide based material has two or more levels of porosity and structural order, and wherein the internal structure of said nanometer size building units does not give rise to Bragg type diffraction in a powder X-ray diffraction pattern of said substantially crystalline mesoporous oxide based material, comprising the steps of (a) generating said nanometer size building units having zeolite framework by means of a mediating agent selected from the group consisting of tetraalkylammonium ions, tetraalkylphosphonium ions or gemini (dimeric) tetraalkylammonium ions wherein the alkyl group has from 2 to 4 carbon atoms, and (b) assembling said nanometer size building units through interaction with said one or more amphiphilic non-anionic substances to yield a mesoporous oxide based material.
A process for fixing or immobilizing a biologically active species in a substantially ordered mesoporous oxide-based material, wherein said substantially ordered oxide based-material has one or more levels of porosity and structural order, provided that when said ordered oxide based material has a single level of porosity and structural order it is obtained in the absence of an alpha-tocopherol polyethylene glycol ester templating biomolecule.
Dependencies are inferred from the claim text.