Rapidly disintegrating gelatinous coated tablets
AssigneeMcNeil-PPC, Inc.
InventorsRoger A. Rinker, Nicholas J. Casale, James H. Comly, Brenda Pollock, Atul Ayer, Johan Geerke, Martin Costello, Dennis Wieand, Kishor Parekh
Life of this patent
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Abstract
The present invention relates to an improved gelatinous coated dosage form having two end regions coated with gelatinous materials and an exposed circumferential band. Openings are provided in at least the exposed band to reveal the core material. The invention also relates to methods for manufacturing such gelatinous coated dosage forms.
Claims18
1-11. (canceled)
A dosage form comprising:
- a) a core having an exterior surface and first and second ends;
- b) a subcoating over portions of the exterior surface of the core;
- c) a first gelatinous coating over at least part of the subcoating;
- and
- d) a second gelatinous coating over at least part of the subcoating;
- wherein the first and second gelatinous coatings are provided on said first and second ends of the core;
- wherein said first and second gelatinous coatings form a gap through which the subcoating is exposed;
- and
- wherein the subcoating weight gain is less than or equal to about 3%.
A dosage form comprising:
- a) a core having an exterior surface and first and second ends and comprising one or more active ingredients;
- b) a first gelatinous coating over at least part of the core;
- and
- c) a second gelatinous coating over at least part of the core;
- wherein the first and second gelatinous coatings are provided on said first and second ends of the core;
- wherein the total level of said first and second gelatinous coatings is from about 3 to about 10 weight percent based on the weight of the core;
- and
- wherein the dissolution of one or more active ingredients contained in the core reaches the USP specifications for amount dissolved immediate release tablets containing that particular active ingredient in not more than half the time specified in the USP method.
A dosage form comprising:
- a) a core having an exterior surface with a subcoating and first and second ends;
- b) a first gelatinous coating over at least part of the core;
- and
- c) a second gelatinous coating over at least part of the core;
- wherein the first and second gelatinous coatings are provided on said first and second ends of the core;
- wherein the total level of said subcoating is not more than about 3 weight percent based on the weight of the uncoated core;
- and
- wherein said first and second gelatinous coatings are substantially free of visible bubble defects.
25-28. (canceled)
A method for producing a dosage form comprising:
- a) coating a compressed tablet having two opposing ends with a subcoating material provided over at least part of its exterior surface;
- b) providing one end of the subcoated compressed tablet in a gelatinous material;
- c) providing a second end of the subcoated compressed tablet in a gelatinous material;
- and
- wherein the subcoating layer weight gain is less than or equal to about 3%.
A method for producing a dosage form comprising:
- a) making a compressed tablet having two opposing ends;
- b) providing one end of the compressed tablet with a gelatinous material;
- and
- c) providing a second end of the compressed tablet with a gelatinous material;
- wherein the gelatinous coatings resulting from steps b) and c) form a gap that exposes an exterior surface of the compressed tablet from step a).
Dependencies are inferred from the claim text.