Capsule for the prevention of cardiovascular diseases

A capsule which comprises:

• (i) a) w coated tablet(s) comprising 40.5 mg of acetylsalicylic acid and x coated tablet(s) comprising 81 mg of acetylsalicylic acid, wherein w is an integer chosen from 0 and 1, and x is an integer chosen from 0, 1 and 2, such that the total amount of acetylsalicylic acid is from 40.5 to 162 mg and w+x is 1 or 2;
• or
• b) y coated tablet(s) comprising 50 mg of acetylsalicylic acid and z coated tablet(s) comprising 100 mg of acetylsalicylic acid, wherein y is an integer chosen from 0 and 1, and z is an integer chosen from 0, 1 and 2, such that the total amount of acetylsalicylic acid is from 50 to 200 mg and y+z is 1 or 2;
• (ii) a) s coated tablet(s) comprising 20 mg of simvastatin and t coated tablet(s) comprising 40 mg of simvastatin, wherein s is an integer chosen from 0, 1 and 2, and t is an integer chosen from 0, 1 and 2, such that the total amount of simvastatin is from 20 to 80 mg and s+t is 1 or 2;
• or
• b) u coated tablet(s) comprising 20 mg of pravastatin or a pharmaceutically acceptable salt thereof and v coated tablet(s) comprising 40 mg of pravastatin or a pharmaceutically acceptable salt thereof, wherein u is an integer chosen from 0, 1 and 2, and v is an integer chosen from 0, 1 and 2, such that the total amount of pravastatin or a pharmaceutically acceptable salt thereof is from 20 to 80 mg and u+v is 1 or 2;
• and
• (iii) a) p coated tablet(s) comprising 5 mg of lisinopril or a hydrated form, q coated tablet(s) comprising 10 mg of lisinopril or a hydrated form and r coated tablet(s) comprising 20 mg of lisinopril or a hydrated form, wherein p is an integer chosen from 0 and 1, q is an integer chosen from 0 and 1, and r is an integer chosen from 0, 1 and 2, such that the total amount of lisinopril or hydrated form is from 5 to 40 mg and p+q+r is 1, 2 or 3;
• or
• b) k coated tablet(s) comprising 2.5 mg of ramipril, m coated tablet(s) comprising 5 mg of ramipril and n coated tablet(s) comprising 10 mg of ramipril, wherein k is an integer chosen from 0 and l, m is an integer chosen from 0 and 1, and n is an integer chosen from 0, 1 and 2, such that the total amount of ramipril is from 2.5 to 20 mg and k+m+n is 1, 2 or 3;
• or
• c) h coated tablet(s) comprising 2 mg of perindopril or a pharmaceutically acceptable salt thereof, i coated tablet(s) comprising 4 mg of perindopril or a pharmaceutically acceptable salt thereof, and j coated tablet(s) comprising 8 mg of perindopril or a pharmaceutically acceptable salt thereof, wherein h is an integer chosen from 0 and 1, i is an integer chosen from 0 and 1, and j is an integer chosen from 0, 1 and 2, such that the total amount of perindopril or a pharmaceutically acceptable salt thereof is 2 to 16 mg and h+i+j is 1, 2 or 3;
• wherein:
• the acetylsalicylic acid tablets are coated with a partially hydrolysed polyvinyl alcohol comprising film;
• the simvastatin tablets are coated with a hydroxypropylmethyl cellulose comprising film;
• the pravastatin or pharmaceutically acceptable salt tablets are coated with a hydroxypropylmethyl cellulose comprising film;
• the lisinopril or hydrated form tablets are coated with a partially hydrolysed polyvinyl alcohol comprising film;
• the ramipril tablets are coated with a partially hydrolysed polyvinyl alcohol comprising film;
• and
• the perindopril or pharmaceutically acceptable salt tablets are coated with a partially hydrolysed polyvinyl alcohol comprising film.