Pharmacuetical tablets containing a plurality of active ingredients
AssigneeAccu-Break Technologies, Inc.
InventorsAllan S. Kaplan, Lawrence Solomon
Life of this patent
Estimating the term…
Abstract
Described are stable compressed pharmaceutical dosage forms, such as tablets, layered so that incompatible active ingredients can be included in a single dosage form, and such that carry-over and intermixing are minimized in the manufacture process.
Claims25
A pharmaceutical dosage form comprising a layered structure comprising two or more active pharmaceutical ingredients, said dosage form comprising at least four segments, including a bottom end segment and a top end segment, wherein a first segment comprises a first active pharmaceutical ingredient, a second segment comprises an active pharmaceutical ingredient, a third segment comprises a composition compatible with said first and second segments, said third segment having a position between said first and second segments, and a fourth segment comprising a composition that is compatible with said first or second segments, said fourth segment forming said top end segment or said bottom end segment.
A method for preparing a layered dosage form having at least two active pharmaceutical ingredients and at least four segments, including a top end segment and a bottom end segment, said method comprising
- using a multi-layer tablet press, filling a tablet die with a first composition comprising a first active pharmaceutical ingredient to form a first segment,
- filling the tablet die with a second composition comprising a second active pharmaceutical ingredient to form a second segment,
- filling the tablet die with a third composition to form a third segment that is compatible with the first and second segments, said third segment having a position between said first and second segments, and
- filling the tablet die with a fourth segment comprising a composition that is compatible with said first or second segments, said fourth segment forming a top end segment or a bottom end segment of the dosage form.
A method for reducing intermixing or transference of an active ingredient from one segment to another segment in a segmented dosage form comprising a first, second, third, and fourth segment, including a top end segment and a bottom end segment, and comprising at least two active ingredients, said method comprising
- disposing a first composition comprising an active ingredient in a tablet die to form said first segment;
- disposing a second composition comprising a second active ingredient in a tablet die to form said second segment;
- disposing a third composition substantially free of the first and second active ingredients, said third composition having a position between said first and second segments;
- and
- disposing a fourth composition substantially free of said first or second active ingredient to form said fourth segment as a top end or bottom end segment.
Dependencies are inferred from the claim text.