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US 2011/0086082 A1Published application
Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility
AssigneeInnovational Holdings, LLC
InventorsTheodore L. PARKER, Stephen Hunter Diaz, John F. Shanley, Diane Mai Huong Dang, Thai Minh Nguyen
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Abstract
An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected to achieve a desired release rate.
Claims30
An implantable drug delivery device comprising:
- an implantable device configured to be implanted within tissue, lumens, or organs of the body;
- a beneficial agent provided in or on the implantable medical device for delivery to the tissue, lumen, or organ of the body to achieve a desired beneficial effect;
- wherein the beneficial agent is provided in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected to achieve a desired release rate.
A method of forming an implantable drug delivery device comprising:
- selecting an implantable device configured to be implanted within tissue, lumens, or organs of the body;
- providing a beneficial agent in two different forms, a first form having a higher solubility and a second form having a lower solubility;
- selecting a proportion of the two different forms to achieve a desired release rate;
- affixing the beneficial agent in the two different forms and in the selected proportion to the implantable device.
1 more element
Dependencies are inferred from the claim text.