Combinations of niacin and an oxicam
AssigneeDr. Reddy's Laboratories, Inc.
InventorsPradeep Jairao Karatgi, Thilek Kumar Muniyappan, Shantanu Yeshwant Damle, Sesha Sai Marella, Harshal Prabhakar Bhagwatwar, Raviraj Sukumar Pillai, Ish Kumar Khanna
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Abstract
Pharmaceutical formulations comprising a combination of niacin and an oxicam NSAID, for oral administration, and methods of preparing the formulations.
Claims28
A pharmaceutical formulation comprising a therapeutically effective dyslipidemia-treating amount of niacin, and an oxicam NSAID in an amount sufficient to reduce flushing side effects induced by administering the niacin.
A pharmaceutical formulation comprising:
- (a) a core comprising niacin;
- (b) an enteric coating covering the core;
- and (c) a layer comprising an oxicam NSAID over the enteric coating.
A pharmaceutical formulation containing niacin and an oxicam NSAID, providing a release of at least about 20% of contained oxicam NSAID and no more than about 10% release of contained niacin, within about 30 minutes after immersion into an aqueous medium having pH values less than about 4.
Dependencies are inferred from the claim text.