Lentival Vector-Based Vaccine
AssigneeInstitut Pasteur
InventorsPierre Charneau, Philippe Despres
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Abstract
Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.
Claims34
A lentiviral vector comprising a heterologous nucleic acid encoding an antigen, and wherein expression of the antigen in a cell of an animal elicits a humoral response in said animal, for the preparation of a medicament able to produce antibodies when administered to said animal.
A lentiviral vector comprising a heterologous nucleic acid selected in the group consisting of an heterologous nucleic acid encoding a surface protein from a microorganism, or a fragment thereof, and a variant of a surface membrane protein or a fragment thereof, with an acceptable physiological carrier and/or an adjuvant, for the preparation of a vaccine against a microorganism infection, able to be administered to an animal in need thereof, one or more times.
An immunogenic composition comprising a lentiviral vector, wherein the lentiviral vector comprises a heterologous nucleic acid encoding an antigen in an amount sufficient to induce an immunogenic or protective response in vivo, and a pharmaceutically acceptable carrier therefor.
A lentiviral vector that directs the expression of a heterologous nucleic acid, wherein the heterologous nucleic acid encodes envelope E-glycoprotein from West Nile Virus, a variant thereof or fragments thereof, and wherein the vector comprises a promoter selected from cytomegalovirus immediate early promoter, CAG promoter, EF1 alpha promoter, PGK promoter, SVero promoter, and MND promoter.
A lentiviral vector that directs the expression of a heterologous nucleic acid, wherein the vector comprises cytomegalovirus immediate early promoter, and wherein the heterologous nucleic acid comprises green fluorescent protein.
A lentiviral vector comprising a heterologous nucleic acid encoding an antigen, and wherein the antigen elicits antibodies against the pathogenic agent, for the preparation of a vaccine against a pathogenic agent, able to be administered to an animal in need thereof.
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Dependencies are inferred from the claim text.