Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
AssigneeThomas Jefferson University
InventorsScott A. Waldman, Jason Park, Stephanie Schulz
Life of this patent
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Abstract
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.
Claims21
An in vitro method of screening an individual for metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from an individual to determine whether CDX2 is being expressed by cells in said sample wherein expression of said CDX2 indicates a possibility of metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells in said sample.
2-33. (canceled)
A vaccine composition comprising:
- a) a protein comprising at least one epitope of human sucrase isomaltase protein or a nucleic acid molecule that encodes said protein;
- and
- b) a pharmaceutically acceptable carrier or diluent.
A haptenized protein comprising at least one epitope of human sucrase isomaltase protein.
Dependencies are inferred from the claim text.