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US 2011/0086055 A1Published application
Her2 peptides
AssigneeThe Ohio State University Research Foundation
InventorPravin Kaumaya
Life of this patent
Estimating the term…
Abstract
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include epitopes of the HER-2 proteins.
Claims20
An immunogenic composition comprising a chimeric peptide, wherein the chimeric peptide comprises a HER-2 B epitope, a T helper (Th) epitope, and a linker joining the HER-2 B epitope to the Th epitope, wherein:
- the HER-2 B epitope consists of a sequence selected from the group consisting of:
- SEQ ID NO:
- 2
- CHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVA,;
- SEQ ID NO:
- 3
- VACAHYKDPPFCVA,;
- SEQ ID NO:
- 4
- VARCPSGVKPDLSYMPIWKFPDEEGACQPL,;
- SEQ ID NO:
- 5
- IWKFPDEEGACQPL,;
- SEQ ID NO:
- 7
- ACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEK,;
- SEQ ID NO:
- 8
- CPLHNQEVTAEDGTQRCEK,;
- and
- SEQ ID NO:
- 9
- CPINCTHSCVDLDDKGCPAEQRAS,;
- the Th epitope comprises a sequence selected from the group consisting of:
- KLLSLIKGVIVHRLEGVE,;
- SEQ ID NO:
- 10
- NSVDDALINSTIYSYFPSV,;
- SEQ ID NO:
- 11
- PGINGKAIHLVNNQSSE,;
- SEQ ID NO:
- 12
- QYIKANSKFIGITEL,;
- SEQ ID NO:
- 13
- FNNFTVSFWLRVPKVSASHLE,;
- SEQ ID NO:
- 14
- LSEIKGVIVHRLEGV,;
- SEQ ID NO:
- 15
- FFLLTRILTIPQSLN,;
- SEQ ID NO:
- 16
- and
- TCGVGVRVRSRVNAANKKPE,;
- SEQ ID NO:
- 17
- and
- the linker comprises a sequence that is from 1 to 15 amino acids in length.
48 more elements
Dependencies are inferred from the claim text.