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US 2011/0086053 A1Published application
Glycolipids And Analogues Thereof As Antigens For NKT Cells
AssigneesThe Rockefeller University, The Scripps Research Institute
InventorsMoriya Tsuji, David D. Ho, Chi-Huey Wong, Douglass Wu, Masakazu Fujio, Xiangming Li
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Abstract
This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
Claims40
A compound represented by the structure of formula 1:
- wherein, R═COOR1 or CH2OR1;
- R1═H or an alkyl group;
- R2═H Or SO3−;
- R3═H or OH;
- R3′═H or OH;
- R4 and R4′ are independently chosen from
- (a) H,
- (b) alkyl;
- (c) alkenyl;
- and
- (d) oxaalkyl;
- R5═OH, acetamido or a halogen atom;
- wherein if R═CH2OR1, R2═H, R3 is OH and R3′ is H, then one of the following is true:
- R5=acetamido, halogen atom or OH in an axial position;
- R4═H, or unsaturated or saturated alkyl chain having 9 carbon atoms or fewer;
- or
- R4′═H, or unsaturated or saturated alkyl chain having 20 carbon atoms or fewer.
14 more elements
A compound represented by the structure of formula 11:
- wherein, R═COOR1 or CH2OR1;
- R1═H or an alkyl group;
- R2═H or SO3−;
- R3═H or OH;
- R4═H, unsaturated or saturated, alkyl group;
- R5═OH, acetamido or a halogen atom;
- and
- R6═X-A
- A=
- dialkyl phenyl;
- X=alkyl, alkenyl, alkoxy, thioalkoxy, substituted furan, or unsubstituted furan;
- Y═N or C
- R7=halogen, H, phenyl, alkyl, alkoxy, nitro or CF3;
- and
- R8=methyl or H;
12 more elements
A compound represented by the structure of formula (17):
- wherein
- R4 and R6 are independently selected from:
- (a) alkyl,
- (b) alkenyl,
- (c) alkyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- and
- (d) alkenyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl.
4 more elements
Dependencies are inferred from the claim text.