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US 2011/0086048 A1Published application
Detection of human immunodeficiency virus co-receptor tropism in aviremic subjects
AssigneeUniversity of Massachusetts
InventorMario Stevenson
Life of this patent
Estimating the term…
Abstract
Methods for detecting human immunodeficiency virus (HIV) co-receptor tropism or replication-competent virus in aviremic subjects, and methods of selecting optimal therapies for aviremic subjects.
Claims20
A method of determining co-receptor tropism of replication competent virus in an HIV-positive subject who has less than 50 cell-free viral RNA molecules/ml of serum, the method comprising:
- providing a sample comprising a cell from the subject;
- detecting an HIV 2-LTR circle DNA molecule in the sample;
- and
- determining the co-receptor tropism of the 2-LTR circle DNA;
- wherein the co-receptor tropism of the 2-LTR circle DNA indicates the co-receptor tropism of the replication competent virus in the subject.
2 more elements
A method of treating an HIV-infected subject who has less than 50 cell-free viral RNA molecules/ml of serum, the method comprising:
- providing a sample comprising a cell from the subject;
- detecting an HIV 2-LTR circle DNA molecule in the sample;
- determining the co-receptor tropism of the 2-LTR circle DNA;
- determining co-receptor tropism of replication-competent virus in the subject based on the co-receptor tropism of the 2-LTR circle DNA;
- selecting an entry inhibitor suitable for the HIV co-receptor tropism of the virus in the subject;
- and
- administering an effective amount of the selected entry inhibitor to the subject, thereby treating the subject.
4 more elements
Dependencies are inferred from the claim text.