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AssigneeThe UAB Research Foundation
InventorsRandall S. Davis, Max D. Cooper, Chuen-Miin Leu, Goetz R. A. Ehrhardt
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Provided herein are antibodies having the same epitope specificity as an antibody produced by the hybridoma cell line deposited with the American Type Culture Collection as hybridoma 4-2A6, 1-5A3, or 1-3B4. Further provided herein are methods of identifying and selecting cells that express FcRH1 or FcRH4. Methods of diagnosing and treating a subject with a malignancy of a hematopoietic cell lineage or an autoimmune disease and methods of modulating a humoral immune response in a subject are also provided herein. Further provided herein are polypeptides comprising one or more complementary determining regions of the disclosed antibodies and nucleic acids that encode the disclosed polypeptides.
An antibody having the same epitope specificity as an antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6236.
An antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6236.
A human antibody that binds to the same epitope of an FcRH4 receptor molecule as the monoclonal antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6236.
A cell of the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6236.
An antibody having the same epitope specificity as an antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6192.
An antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC # PTA-6192.
A human antibody that binds to the same epitope of an FcRH1 receptor molecule as the monoclonal antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC # PTA-6192.
A cell of the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC # PTA-6192.
An antibody having the same epitope specificity as an antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6219.
An antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6219.
A human antibody that binds to the same epitope of an FcRH1 receptor molecule as the monoclonal antibody produced by the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6236.
A cell of the hybridoma cell line deposited under the American Type Culture Collection Accession Number ATCC # PTA-6219.
Dependencies are inferred from the claim text.