Centrosomal Proteins, Nucleic Acids and Method of Use Thereof
OwnerQingshen Gaoinventor
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Abstract
The present invention provides novel isolated centrobin polynucleotides and polypeptides encoded by the centrobin polynucleotides. The invention additionally provides methods of inhibiting cell growth by contacting a cell with a centrobin inhibitor.
Claims20
An isolated polypeptide at least 95% identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4 or a fragment thereof at least 400 amino acids in length, wherein said polypeptide or fragment binds BRCA-2.
An antibody that selectively binds to a centrobin polypeptide, and fragments, or derivatives of said antibody.
A method of treating a subject suffering from or predisposed to a cancer, comprising administering to said subject a centrobin inhibitory compound.
A method for selecting an inhibitor of aberrant cell proliferation associated with a cell proliferative disease or disorder that is associated with an altered centrosome number comprising the steps of contacting a cell having altered centrosome number with a candidate compound;
- and selecting a compound that decreases centrobin expression, wherein a decrease in centrobin expression indicates that said compound inhibits aberrant cell proliferation.
Dependencies are inferred from the claim text.