Prevention of hiv infection
AssigneeThe Trustees of the University of Pennsylvania
InventorsDrew Weissman, Stoddard Earl
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Abstract
This invention relates to methods compositions and devices for inhibiting infection of a subject's host cell by HIV. Specifically, the invention relates to methods and compositions capable of inhibiting the binding and subsequent infection by HIV of a host cell through the inhibition of the interaction between gp-340 expressed on the cell surface and V3 loop on the HIV envelope and devices comprising these compositions.
Claims67
A method of inhibiting binding of an immunodeficiency virus to a genital tract tissue in a subject, comprising the step of:
- contacting the genital tract with an effective amount of an agent capable of inhibiting the binding between immunodeficiency virus and gp-340, thereby inhibiting binding of the immunodeficiency virus to the genital tract tissue.
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A composition for treating immunodeficiency virus binding and subsequent infection of a target host cell comprising:
- an effective amount of an agent capable of binding to gp-340, an effective amount of an antibody specific against gp-340 that is expressed on the host cell surface or a fragment thereof, or their combination.
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A method of inhibiting attachment of an immunodeficiency virus to a host cell, comprising the step of contacting a gp340 protein expressed on the host cell, or the host cell with a gp340-specific antibody or a fragment thereof, thereby eliminating the attachment site on the host cell for the virus.
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A contraceptive device comprising:
- an agent capable of binding to gp340 expressed on a host cell;
- an effective amount of an antibody or a fragment thereof specific against gp-340 that is expressed on the surface of a vaginal, an endocervical or an ectocervical primary epithelial cell, or a combination thereof.
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A method to identify a ligand to membrane bound gp340, comprising:
- contacting a membrane bound gp340 with a candidate ligand, under conditions wherein, in the absence of said candidate ligand, said membrane bound gp340 is capable of attaching to the third hypervariable region of gp-120 (V3 loop) expressed on an immunodifeciency virus envelope;
- and detecting concentration or activity of bound virus' envelope, wherein reduction in concentration or activity of said bound virus' envelope in the manner associated with the binding of said membrane bound gp340 indicates that said candidate ligand is a membrane bound gp340
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Dependencies are inferred from the claim text.