Prevention or Treatment of Immune-Relevant Disease by Modification of Microfloral Populations
AssigneeTrustees of Dartmouth College
InventorsLloyd H. Kasper, Javier Ochoa-Repáraz
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Abstract
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
Claims17
A method for preventing or treating an immune-relevant disease comprising administering to a subject in need of treatment an effective amount of one or more antibiotics to modulate commensal microbiota populations and subsequently administering exogenous microflora that express capsular polysaccharide thereby preventing or treating an immune-relevant disease in the subject.
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A method for transferring protection to an immune-relevant disease comprising isolating regulatory T cells from a first subject colonized with a Bacteroides and administering said regulatory T cells to a second subject having an immune-relevant disease so that protection to the immune-relevant disease is transferred from the first subject to the second subject.
Dependencies are inferred from the claim text.