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AssigneePiramal Healthcare (Canada) Ltd.
InventorsCaroline D. HOEMANN, Michael D. Buschmann, Marc D. Mckee
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The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.
A self-gelling and injectable polymer composition for repairing or regenerating a tissue of a patient comprising a polymer solution admixed with blood or a component thereof,
A chitosan solution for cell delivery into a tissue to repair or regenerate a tissue in vivo, the chitosan solution comprising 0.5-3% w/v of chitosan and being formulated to be thermogelling, the solution being mixed with cells prior to being injected into the tissue to be repaired or regenerated.
A chitosan solution for culturing cells in vitro, the chitosan solution comprising 0.5-3% w/v of chitosan and being formulated to be thermogelling, the solution being mixed with cells prior to being cultured in vitro.
Dependencies are inferred from the claim text.