Diagnosis and treatment of epithelial cancers using labeled/conjugated progastrin peptides
OwnerPomila Singhinventor
Life of this patent
Estimating the term…
Abstract
The current invention provides Progastrin peptides that specifically bind Annexin A2 overexpressed by epithelial cancers. The invention includes isolated homing Progastrin peptides conjugated to an imaging agent and methods of using the same for the diagnosis of epithelial cancers. Also encompassed are Progastrin peptides conjugated to cytotoxic agents such as Camptothecin, Doxorubicin, Paclitaxel and derivatives thereof, and methods of treating epithelial cancer using the same.
Claims32
An isolated homing progastrin peptide that specifically binds Annexin A2 expressed by a tumor cell.
An isolated homing progastrin peptide of sequence shown in SEQ ID NO:
- 1, that specifically binds annexin2 expressed by a tumor cell.
A composition useful for diagnosis of epithelial cancer comprising:
- an isolated homing progastrin peptide of sequence shown in SEQ ID NO:
- 1 conjugated to an imaging agent.
A composition useful for treating epithelial cancer in an individual comprising:
- an isolated homing progastrin peptide of sequence shown in SEQ ID NO:
- 1 conjugated to a cytotoxic agent.
A method of detecting epithelial cancer in an individual comprising:
- administering to the individual an isolated homing progastrin peptide of sequence shown in SEQ ID NO:
- 1 conjugated to an imaging agent;
- and
- determining the location of said imaging in the individual, wherein the location corresponds to the cancer.
A method of treating epithelial cancer in an individual comprising:
- administering to the individual a pharmacologically effective amount of an isolated homing progastrin peptide of sequence shown in SEQ ID NO:
- 1 conjugated to a cytotoxic agent or a pharmaceutical derivative thereof.
An isolated homing progastrin peptide that specifically binds annexin2 expressed by a tumor cell, wherein said peptide has a sequence 95% identical to the amino acid sequence shown in SEQ ID NO:
- 1.
An isolated homing progastrin peptide that specifically binds annexin2 expressed by a tumor cell, wherein said peptide has a sequence 90% identical to the amino acid sequence shown in SEQ ID NO:
- 1.
An isolated homing progastrin peptide that specifically binds annexin2 expressed by a tumor cell, wherein said peptide has a sequence 85% identical to the amino acid sequence shown in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.