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US 2011/0085978 A1Published application
Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors
AssigneeNeuroSearch A/S
InventorsDan Peters, Lars Christian Rønn, Karin Sandager Nielsen, Jørgen Scheel-Krüger
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Abstract
This invention provides novel quinolinylamide derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
Claims15
A quinolinylamide derivative represented by Formula
- a stereoisomer thereof or a mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein
- X represents CH or N;
- n is 2 or 3;
- R′ represents hydrogen or alkyl;
- and
- Ar represents phenyl or pyridinyl, which phenyl and pyridinyl are optionally substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halo, trifluoromethyl, nitro and cyano.
3 more elements
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(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.