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US 2011/0085974 A1Published application
Small molecule ligand-drug conjugates for targeted cancer therapy
AssigneesCedars-Sinai Medical Center, Emory University
InventorsLeland W.K. Chung, Xiaojian Yang, Jianjun Cheng, Rong Tong
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Abstract
The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.
Claims75
A small molecule conjugate compound comprising:
- a targeting ligand;
- a therapeutic agent and/or an imaging agent;
- and
- a linker connecting the ligand to the therapeutic agent and/or the imaging agent.
1 more element
A method of treating cancer in a patient in need thereof, comprising:
- providing a small molecule conjugate compound comprising:
- a targeting ligand;
- a therapeutic agent and/or an imaging agent;
- and
- a linker connecting the ligand to the therapeutic agent and/or the imaging agent.
2 more elements
Dependencies are inferred from the claim text.