Device and method for localizing an object of interest in a subject

Device (10) for localizing an object (15, 220, 225, 230) of interest in a subject (20), comprising:

• a registration unit (25) for registering (120) a three-dimensional representation of the subject, which comprises a plurality of segments corresponding to a plurality of structural regions of the subject, with a two-dimensional image (200), wherein the registration unit is adapted for defining a plurality of areas (205, 210, 215) in the image corresponding to the plurality of segments such that at least one area of the plurality of areas is associated with a respective region of the plurality of regions, and
• a localization unit (30) for localizing (125) the object, wherein the localization unit is adapted for extracting an indication of the object from the image by processing the image, wherein the processing of the image is limited to an object area of the plurality of areas which is associated with a predetermined object region.