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US 2011/0085168 A1Published application
Luminescence Reference Standards
AssigneeLife Technologies Corporation
InventorsJ. Michael Phillips, Aldrich N.K. Lau, Mark F. Oldham, Kevin S. Bodner, Steven J. Boege, Donald R. Sandell, David H. Tracy
Life of this patent
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Abstract
The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
Claims18
A luminescence reference device comprising:
- a sample-support device, wherein the sample-support device is comprised of a plurality of fluid compartments;
- and
- at least one emissive element distributed in the plurality of fluid compartments of the sample-support device;
- wherein the at least one emissive element comprises at least one of a subtraction-based material or an addition-based material.
1 more element
A system for biological reactions, comprising:
- a sample support configured to support one or more biological samples;
- a reference comprising:
- a light-producing element;
- at least one of a spectral filter layer, an intensify filter layer, or a protective coating layer;
- and
- a light source configured to illuminate the one or more biological samples;
- a detector to receive light from the one or more biological samples;
- an optical system configured to direct light from the reference to the detector;
- wherein the reference is configured to provide one or more of verification of system alignment or location of system grids.
6 more elements
A method of verifying alignment of a system for biological reactions, comprising:
- providing a sample support configured to support one or more biological samples;
- providing a reference comprising:
- a light-producing element;
- at least one of a spectral filter layer, an intensify filter layer, or a protective coating layer;
- and
- illuminating the one or more biological samples with a light source;
- receiving light from the one or more biological samples at a detector;
- directing light from the reference to the detector using an optical system;
- based at least in part on the light directed from the reference to the detector, verifying system alignment.
6 more elements
Dependencies are inferred from the claim text.