Loading patent…
AssigneeTopigen Pharmaceutique Inc.
InventorsPaolo Renzi, Khalid Zemzoumi, Helene D'Anjou
Estimating the term…
The invention relates to therapeutic antisense oligonucleotides directed against genes coding for phosphodiesterase (PDEs) and the use of these in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial.
A pharmaceutical composition for treating disease associated with reduced cAMP levels, said composition comprising a pharmaceutically acceptable carrier and at least two antisense oligonucleotide compounds each being capable of inhibiting expression of a target PDE consisting of PDE7A and PDE4D respectively, each oligonucleotide being directed against at least a portion of a nucleic acid sequence encoding PDE7A and PDE4D respectively, each oligonucleotide compound being present at a concentration that exhibits less than 20% inhibition of expression of its target PDE, the combination exhibiting more than 20% inhibition of expression, and at least doubling the inhibition of expression of at least one target PDE resulting in a more than additive inhibition of expression of PDE7A and PDE4D.
Dependencies are inferred from the claim text.