Molecular markers for autism

A diagnostic method for at least 40% of ADSs forms for the determination of the phosphorylation of statherin, histatin and PRP-1 and PRP-3 salivary isoforms comprising the following steps:

• a patient's salivary sample is collected;
• said sample is subjected to examination for identification and quantification of the phosphorylation levels of at least one of the proteins selected from the group comprising statherin, histatin, PRP-1 and PRP-3;
• phosphorylation data obtained from said samples are compared to normal standard values;
• a divergence of these values in the form of hypo-phosphorylation indicates presence of ASDs.

A diagnostic method for at least 80% of ASDs forms not correlated to mental retardation or with border-line cognitive skills for the determination of the phosphorylation of statherin, histatin and PRP-1 and PRP-3 salivary isoforms comprising the following steps:

• a patient's salivary sample is collected;
• said sample is subjected to examination for identification and quantification of the phosphorylation levels of at least one of the proteins selected from the group comprising statherin, histatin, PRP-1 and PRP-3;
• phosphorylation data obtained from said samples are compared to normal standard values;
• a divergence of these values in the form of hypo-phosphorylation indicates presence of ASDs not correlated to mental retardation or with border-line cognitive skills.