Stat3 inhibiting compositions and methods
AssigneeCharlesson, LLC
InventorRafal A. Farjo
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Abstract
STA-21-related compounds, for example CLT-005, are shown to prevent dimerization of STAT3, thereby inhibiting STAT3 activity. Inhibition of STAT3 activity is shown to reduce intraocular inflammation and neovascularization, symptoms of eye-related diseases such as age-related macular degeneration. Inhibition of STAT3 prevents STAT3 from transcriptionally activating downstream gene targets that are known to be associated with retinal inflammation and neovascularization and such disorders as age-related macular degeneration.
Claims28
A composition comprising:
- a pharmaceutical carrier and an amount, therapeutically effective for the treatment of an eye-related disease, of an agent having the formula:
- wherein R1 and R2 are independently selected from H and OH;
- and
- wherein the composition is prepared for administration topically or intravitreally.
A method of treating an eye-related disease in a subject, comprising:
- administering to the subject's eye a composition comprising a pharmaceutical carrier and an amount, therapeutically effective for the treatment of the eye-related disease, of an agent having the formula:
- wherein R1 and R2 are independently selected from H and OH.
A method of reducing expression of pro-inflammatory and pro-angiogenic molecules in a subject's eye, comprising:
- administering to the subject's eye a composition comprising a pharmaceutical carrier and an amount, therapeutically effective for reducing expression of pro-inflammatory and pro-angiogenic molecules in the subject's eye, of an agent having the formula:
- wherein R1 and R2 are independently selected from H and OH.
A method of decreasing retinal vascular permeability in a subject's eye, comprising:
- administering to the subject's eye a composition comprising a pharmaceutical carrier and an amount, therapeutically effective for reducing retinal vascular permeability, of an agent having the formula:
- wherein R1 and R2 are independently selected from H and OH.
Dependencies are inferred from the claim text.