Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method
AssigneeJapan Science and Technology Agency
InventorsShu Kobayashi, Yasuhiro Yamashita, Kazutaka Seki
Life of this patent
Estimating the term…
Abstract
Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.
Claims37
A manufacturing method of starting materials of diamino acid derivatives represented by the following general formula [II], said manufacturing method comprising reacting a compound represented by the following general formula [I] with a compound represented by the following general formula [V].
- (R2 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. All of R2 may be identical to each other, and may differ from each other. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
- (R2 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. All of R2 may be identical to each other, and may differ from each other. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
- (R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group.)
A diamino acid derivative starting material, said diamino acid derivative starting material being a compound represented by the following general formula [I].
- (R2 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. All of R2 may be identical to each other, and may differ from each other. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
A diamino acid derivative starting material, said diamino acid derivative starting material being a compound represented by the following general formula [II].
- (R2 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. All of R2 may be identical to each other, and may differ from each other. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
A manufacturing method of diamino acid derivatives, said manufacturing method comprising removing a fluorenyl group of a diamino acid derivative starting material represented by the following general formula [II].
- (R2 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. All of R2 may be identical to each other, and may differ from each other. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
A manufacturing method of starting materials of diamino acid derivatives represented by the following general formula [IV], said manufacturing method comprising reacting a compound represented by the following general formula [III] with a compound represented by the following general formula [V].
- (R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
- (R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
- (R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group.)
A diamino acid derivative starting material, said diamino acid derivative starting material being a compound represented by the following general formula [III].
- (R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group).
A diamino acid derivative starting material, said diamino acid derivative starting material being a compound represented by the following general formula [IV].
- (R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
A manufacturing method of diamino acid derivatives, said manufacturing method comprising removing a fluorenyl group of a diamino acid derivative starting material represented by the following general formula [IV].
- (R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group. R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group. R4 is an electron-withdrawing group. The fluorenyl group is ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group.)
Dependencies are inferred from the claim text.