Methods of use of antiviral compounds

A method for treating an influenza virus-affected disease state or infection comprising the step of administering to a subject in need thereof a composition comprising a compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is hydrogen, hydroxyl, halo, alkoxy, or together with R5 or R6 forms an optionally substituted five- or six-membered carbocyclic or heterocyclic ring;
• R2 and R3 are independently hydrogen, hydroxyl, halo, thiol, (C1-C3)alkylthio, or (C1-C3)alkoxy;
• R4 is hydroxyl, oxo, oxime, amino, a three- to six-membered optionally substituted carbocyclic or heterocyclic ring, or together with R5 or R6 forms an aziridine group;
• R5 and R6 are independently hydrogen, amino, nitro, cyano, hydroxyl, oxo, oximeamino(C1-C3)alkyl, hydroxy(C1-C3)alkylamino, formamidinyl, guanidinyl, oxime, —CH(X)(Y), a three- to six-membered heterocyclic ring, together with R4 forms an aziridine group, or together with R1 forms an optionally substituted five- or six-membered carbocyclic or heterocyclic ring;
• X and Y are independently hydrogen, hydroxyl, (C1-C3)alkyl, amino, amino(C1-C3)alkyl, (C1-C3)alkoxy, or (C1-C3)alkylamino;
• Q is hydrogen or is absent;
• and,
• n is 0 or 1;
• wherein
• if n=0, then at least one of R1, R2, R3, R5, and R6 is not hydrogen, and,
• if R3 is hydrogen, then at least one of the following conditions apply:
• n=1;
• either R5 or R6 comprises moiety that includes at least one carbon atom and at least one nitrogen atom and is other than an amino-substituted cyclohexane or dithiane;
• or, at least one of R5 and R6 is amino or nitro and R1 is hydroxyl.