Polynucleotides encoding class ii cytokine receptor-7
AssigneeZymoGenetics, Inc.
InventorsSI LOK, CHOON J. KHO, ANNA C. JELMBERG, ROBYN L. ADAMS, THEODORE E. WHITMORE, THERESA M. FARRAH
Life of this patent
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Abstract
Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
Claims15
An isolated polynucleotide encoding a polypeptide, said polypeptide comprising the amino acid sequence as shown in residues 30 to 250 of SEQ ID NO:2.
An isolated polynucleotide encoding a polypeptide selected from the group consisting of:
- residues 1 to 250 of SEQ ID NO:2;
- residues 1 to 274 of SEQ ID NO:2;
- residues 1 to 553 of SEQ ID NO:2;
- residues 30 to 250 of SEQ ID NO:2;
- residues 30 to 274 of SEQ ID NO:2;
- residues 30 to 553 of SEQ ID NO:2;
- residues 251 to 274 of SEQ ID NO:2;
- residues 251 to 553 of SEQ ID NO:2;
- and
- residues 275 to 553 of SEQ ID NO:2.
An expression vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment encoding a polypeptide, said polypeptide comprising the amino acid sequence as shown in residues 30 to 250 of SEQ ID NO:2;
- and
- a transcription terminator.
An expression vector comprising the following operably linked elements:
- (a) a transcription promoter;
- (b) a DNA segment encoding a chimeric polypeptide, wherein said chimeric polypeptide is comprised of a first portion and a second portion joined by a peptide bond, said first portion consisting essentially of a polypeptide as shown in residues 30 to 250 of SEQ ID NO:2, and said second portion consisting essentially of an affinity tag;
- and
- (c) a transcription terminator.
Dependencies are inferred from the claim text.