Haemostasis-modulating compositions and uses therefor

A pharmaceutical composition for treating blood loss or coagulation disorders, comprising a snake venom FV polypeptide and a pharmaceutically acceptable carrier or diluent, wherein the composition excludes a snake venom FXa polypeptide, and wherein the snake venom FV polypeptide comprises an amino acid sequence selected from the group consisting of:

• (a) an amino acid sequence that shares at least 90% sequence identity with the sequence set forth in any one of SEQ ID NO:
• 2, 4, 6, 8, 10 or 12;
• or (b) an amino acid sequence which is encoded by a nucleotide sequence that shares at least 90% sequence identity with the sequence set forth in any one of SEQ ID NO:
• 1, 3, 5, 7, 9 or 11;
• or (c) an amino acid sequence which is encoded by a nucleotide sequence that hybridizes under high stringency conditions to a complement of the sequence set forth in any one of SEQ ID NO:
• 1, 3, 5, 7, 9 or 11, wherein the amino acid sequence of (a), (b) or (c) has any one or more activity selected from the group consisting of:
• bleeding-inhibiting activity, clotting time-reducing activity;
• haemostasis-enhancing activity;
• clot lysis time prolonging activity;
• and clot strength-increasing activity.