Novel antibodies against prion protein and uses thereof
AssigneeThe University Court of the University of Edinburgh
InventorsMark William Head, Michael Jones
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Abstract
The present invention relates to a novel antibody which selectively binds to the disease associated form of prion protein (PrPSc) under native conditions and the use thereof in methods of prion disease detection, therapy and disease research in general.
Claims20
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An antibody which is capable of selectively binding aggregated PrP106-126 and the abnormal disease associated PrPSc but not monomeric PrP106-126 and normal host PrPC.
The hybridoma cell line P1:1 as deposited with the ECACC, in accordance with the Budapest Treaty, on the 6 Jun. 2006 and available under the accession number 06060601.
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A method of detecting PrPSc in a sample, comprising the steps of:
- a) providing a sample of tissue extract or bodily fluid;
- b) contacting said sample with an antibody according to clam 1 so that the antibody is able to bind any PrPSc present in the sample;
- and
- c) detecting whether or not PrPSc is present in the sample by virtue of detecting antibody-PrPSc immune-complexes.
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Dependencies are inferred from the claim text.