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US 2011/0040057 A1Published application
Ligand-coupled initiator polymers and methods of use
OwnerStephen J. Chudzik, Dale G. Swaninventors
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Abstract
Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.
Claims2
A ligand-coupled initiator polymer comprising:
- a) a hydrophilic polymeric backbone;
- b) a photoinitiator group selected from the group consisting of acridine orange, camphorquinone, ethyl eosin, eosin Y, erythrosine, fluorescein, methylene green, methylene blue, phloxime, riboflavin, rose bengal, thionine, and xanthine dyes;
- and
- c) a ligand group that can specifically bind to a receptor.
1 more element
A kit comprising:
- a) a ligand-coupled initiator polymer comprising:
- i) an initiator group;
- and
- ii) a ligand group able to specifically bind to a receptor on a surface;
- and
- b) polymerizable material able to form a polymeric layer on the surface upon activation of the initiator group.
3 more elements
Dependencies are inferred from the claim text.