Drug delivery

A method of drug delivery to tissue, comprising:

• inserting into a bodily conduit a catheter including an energy-emitting source so that the energy-emitting source is positioned adjacent tissue to be treated and so that focused energy from the energy-emitting source can heat the tissue to be treated, the catheter defining a central lumen and the energy-emitting source disposed within the central lumen, the catheter also including a compression balloon;
• inflating the compression balloon with a circulating fluid at a temperature and to a pressure sufficient to expand the bodily conduit and to compress the tissue to be treated while the energy-emitting source is controlled to heat the tissue, the inflating including circulating the fluid into the compression balloon and then out of the compression balloon into the central lumen of the catheter;
• injecting into the tissue to be treated a drug encapsulated within a heat-sensitive liposome;
• and
• heating with the energy-emitting source at least a portion of the tissue to be treated to destroy the heated portion and also to activate the heat-sensitive liposome to release the encapsulated drug such that the drug targets the tissue to be treated.