Stem cell targeting and activation using magnetic particles
AssigneeMICA Biosystems Limited
InventorsJon Dobson, Alicia El Haj
Life of this patent
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Abstract
The present invention provides a method of selectively activating and/or targeting stem cells which enables the cells to then be manipulated mechanically in a remote manner wherein the method comprises magnetically manipulating a stem cell in vivo or in vitro by the association of a magnetisable particle within the stem cell.
Claims205
A method of selectively activating and/or targeting stem cells which enables the cells to then be manipulated mechanically in a remote manner.
A method of magnetically manipulating a stem cell which comprises the association of a magnetisable particle with a cell characterised in that the method comprises agonising or antagonising ion channels within a cell by the association of a magnetisable particle with a cell.
A method of treatment of a patient suffering from a disorder in which an ion channel plays a role which comprises the administration to such a patient of magnetisable particles and manipulating stem cell ion channels or the stem cells using a magnetic field external to the body.
A method of inducing a therapeutic effect in a stem cell which comprises agonising or antagonising ion channels within the cell by the association of a magnetisable particle with the cell and magnetically manipulating the magnetisable particle.
A method of treatment which comprises the administration of a therapeutically active agent which may be administered simultaneously, separately or sequentially with a magnetisable particle whilst agonising or antagonising ion channels within a stem cell.
A method of targeting a therapeutically active agent to, a stem cell which comprises agonising or antagonising ion channels within the cell by the association of a magnetisable particle with the cell, magnetically manipulating the magnetisable particle and simultaneously, separately or sequentially administering the therapeutically active agent.
The use of a magnetisable particle in a method of magnetically manipulating a stem cell wherein the method comprises the association of a magnetisable particle with a cell.
The use of a magnetisable particle in the manufacture of a therapy that comprises agonising or antagonising ion channels within a stem cell by the association of the magnetisable particle with a stem cell.
The use according to claim 187 characterised in that the particles have a mean size of 5000 nm or less.
The use of a magnetisable particle in association with a stem cell in the manufacture of a therapy for the treatment of a patient suffering from a disorder in which an ion channel plays a role which comprises the administration to such a patient of magnetisable particles and manipulating the stem cell ion channels or the stem cells using a magnetic field external to the body.
The use of a magnetisable particle in the manufacture of a system for targeting a therapeutically active agent to a cell which comprises agonising or antagonising ion channels within the cell by the association of a magnetisable particle with the cell, magnetically manipulating the magnetisable particle and simultaneously, separately or sequentially administering the therapeutically active agent.
A kit comprising a therapeutically active agent and means for associating a magnetisable particle with a cell.
A method or use substantially as described with reference to the accompanying drawings.
Dependencies are inferred from the claim text.