Pharmaceutical composition effective against biofilms
AssigneeHelmholtz-Zentrum FüR Infektionsforschung GmbH
InventorsBrigitte Kunze, Irene Wagner-Dobler, Herbert Irschik, Heinrich Steinmetz, Dietmar Schummer
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Abstract
The invention provides a compound termed Carolacton having the structure and derivatives thereof for medical use against biofilm formation by bacteria.
Claims24
Use of a compound comprising a structure according to formula III
- wherein each of R1, R2, R3 and R4 independently is selected from the group comprising hydrogen and C1- to C12-alkyl groups, including methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-heptyl, n-isoheptyl, n-pentyl- or isopentyl, n-hexyl, isohexyl and C7 to C12 linear, branched or cyclic, saturated, unsaturated or aromatic hydrocarbon radicals,
- for the production of a pharmaceutical composition for inhibition, reduction or prevention of the generation of bacterial biofilms.
Pharmaceutical composition for medical treatment for the prevention of bacterial biofilm formation, the composition comprising as an active ingredient a compound comprising a structure according to formula III
- wherein each of R1, R2, R3 and R4 independently is selected from the group comprising hydrogen and C1- to C12-alkyl groups, including methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-heptyl, n-isoheptyl, n-pentyl- or isopentyl, n-hexyl, isohexyl and C7 to C12 linear, branched or cyclic, saturated, unsaturated or aromatic hydrocarbon radicals.
Composition for cosmetic purposes for the prevention, inhibition or reduction of bacterial biofilm formation, the composition comprising as an active ingredient a compound according to formula III
- wherein each of R1, R2, R3 and R4 independently is selected from the group comprising hydrogen and C1- to C12-alkyl groups, including methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-heptyl, n-isoheptyl, n-pentyl- or isopentyl, n-hexyl, isohexyl and C7 to C12 linear, branched or cyclic, saturated, unsaturated or aromatic hydrocarbon radicals.
Dependencies are inferred from the claim text.