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US 2011/0034701 A1Published application
One pot process for the preparation of candesartan
AssigneeMylan Laboratories Limited
InventorsDutt Tyagi Om, Nageswara Rao Karusala, Uma Sankara Sastry Tummalapalli, Mohan Bandari, Seeta Ramanjaneyulu Gorantla
Life of this patent
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Abstract
Present invention is to provide one pot synthesis of candesartan without isolating the ester intermediate.
Claims7
A one pot process for the preparation of candesartan (I) comprises:
- (a) reacting cyanobiphenyl benzimidazole (III) with trialkyltin or triaryltin azide in presence of an organic solvent to form candesartan ethylester (II);
- and
- (b) insitu hydrolyzing candesartan ethylester (II) with an alkali followed by treatment with an acid gives candesartan (I).
Dependencies are inferred from the claim text.